Endocrine Abstracts

Background: Prader-Willi syndrome (PWS) is a rare genetic, neurodevelopmental disorder. In adults the syndrome is characterized by muscular hypotonia, hyperphagia, increased risk of morbid obesity and behavioral problems. Endocrine insufficiencies are common, although insufficient function of the hypothalamus-pituitary-adrenal (HPA) axis seems to be rare. The effect of long term exposure to cortisol, which is associated with stress and obesity, is unknown in PWS. Measurement o...